Amorolfine hydrochloride
Synonym(s):(2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride;Amorolfine hydrochloride;Ro 14-4767/002
- CAS NO.：78613-38-4
- Empirical Formula: C21H36ClNO
- Molecular Weight: 353.98
- MDL number: MFCD00903738
- EINECS: 689-236-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Amorolfine hydrochloride?
Description
Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topical treatment of onychomycosis. Mechanistically, it appears to inhibit two stages of the ergosterol biosynthetic pathway, which is necessary for fungal cell viability. Active against a broad spectrum of fungi, amorolfiie hydrochloride is particularly effective against yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.
Chemical properties
Liquid
Originator
Roche (Switzerland)
The Uses of Amorolfine hydrochloride
Amorolfine hydrochloride has been used as an antifungal agent.
The Uses of Amorolfine hydrochloride
antihypertensive
Definition
ChEBI: A hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal ag nt, it is used for the topical treatment of fungal nail and skin infections.
brand name
Loceryl (Hoffmann-LaRoche).
Biochem/physiol Actions
Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.
Properties of Amorolfine hydrochloride
| Boiling point: | 120 C |
| storage temp. | room temp |
| solubility | DMSO: ≥5mg/mL (warmed) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 78613-38-4(CAS DataBase Reference) |
Safety information for Amorolfine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for Amorolfine hydrochloride
| InChIKey | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
Amorolfine hydrochloride manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Acute Research
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