Amiloride hydrochloride dihydrate
- CAS NO.：17440-83-4
- Empirical Formula: C6H8ClN7O.HCl.2H2O
- Molecular Weight: 302.12
- MDL number: MFCD00211292
- EINECS: 620-474-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:21
What is Amiloride hydrochloride dihydrate?
Chemical properties
Pale yellow or greenish-yellow powder.
The Uses of Amiloride hydrochloride dihydrate
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
The Uses of Amiloride hydrochloride dihydrate
Diuretic;Antialdosteron
The Uses of Amiloride hydrochloride dihydrate
An epithelial sodium channel blocker
What are the applications of Application
Amiloride hydrochloride dihydrate is an epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
brand name
Midamor (Merck).
Properties of Amiloride hydrochloride dihydrate
| Melting point: | >240℃ |
| RTECS | UQ2275500 |
| storage temp. | Store at -20°C |
| solubility | Slightly soluble in water and in anhydrous ethanol. |
| form | neat |
| pka | 8.7(at 25℃) |
| form | Solid |
| color | Off-white to yellow |
| Water Solubility | Soluble in water at 50mg/ml |
Safety information for Amiloride hydrochloride dihydrate
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P321:Specific treatment (see … on this label). P405:Store locked up. |
Computed Descriptors for Amiloride hydrochloride dihydrate
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