Amifostine Thiol Dihydrochloride
Synonym(s):2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride;WR-1065;WR-1065 dihydrochloride
- CAS NO.：14653-77-1
- Empirical Formula: C5H14N2S
- Molecular Weight: 134.24306
- MDL number: MFCD00460339
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is Amifostine Thiol Dihydrochloride?
Chemical properties
White Solid
The Uses of Amifostine Thiol Dihydrochloride
A metabolite of Amifostine.
What are the applications of Application
Amifostine Thiol Dihydrochloride is a metabolite of Amifostine
Biochem/physiol Actions
WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.
Storage
Desiccate at -20°C
Properties of Amifostine Thiol Dihydrochloride
| Melting point: | 184-186°C |
| storage temp. | -20°C |
| solubility | H2O: ≥20mg/mL |
| form | powder |
| color | white to off-white |
| Stability: | Hygroscopic |
Safety information for Amifostine Thiol Dihydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Amifostine Thiol Dihydrochloride
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