ALK-IN-6

CAS NO.：2055821-33-3
Empirical Formula: C26H32ClN5O3S
Molecular Weight: 530.08
MDL number: MFCD28359408
Update Date: 2025-04-17 18:22:24

What is ALK-IN-6?

Description

ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1]. IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].

References

[1]. Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1514-1517.

Properties of ALK-IN-6

storage temp.	Store at -20°C
solubility	Soluble in DMSO

Safety information for ALK-IN-6

Computed Descriptors for ALK-IN-6

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