AH 11110 HYDROCHLORIDE
Synonym(s):1-[Biphenyl-2-yloxy]-4-imino-4-piperidin-1-yl-butan-2-ol hydrochloride
- CAS NO.：179388-65-9
- Empirical Formula: C21H27ClN2O2
- Molecular Weight: 374.91
- MDL number: MFCD03093187
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is AH 11110 HYDROCHLORIDE?
The Uses of AH 11110 HYDROCHLORIDE
AH 11110 Hydrochloride is an α1B-adrenoceptor selective drug. AH 11110 Hydrochloride has been shown to interact with α1-adrenoceptors as well as α2-adrenoceptors.
Biological Activity
A subtype-selective ligand for the α 1B -adrenoceptor. The pK i values for binding to rat fibroblast cell membranes expressing α 1B (hamster), α 1A (bovine) and α 1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α 1 subtypes and α 2 receptors in smooth muscle preparations.
References
[1]. erami c, zhang h, ho jg, et al. alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. am j physiol heart circ physiol, 2002, 283(4): h1577-1587.
[2]. eltze m, könig h, ullrich b, et al. failure of ah11110a to functionally discriminate between alpha(1)-adrenoceptor subtypes a, b and d or between alpha(1)- and alpha(2)-adrenoceptors. eur j pharmacol, 2001, 415(2-3): 265-276.
Properties of AH 11110 HYDROCHLORIDE
| storage temp. | −20°C |
| solubility | H2O: ~2.5 mg/mL, soluble |
| form | solid |
| color | slightly yellow |
| Water Solubility | Soluble to 25 mM in water |
Safety information for AH 11110 HYDROCHLORIDE
Computed Descriptors for AH 11110 HYDROCHLORIDE
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