Acetyl chloride

Description

Acetic chloride is a colourless to light yellow liquid with a pungent and choking odour. Acetic chloride is highly flammable and reacts violently with DMSO, water, lower alcohols, and amines to generate toxic fumes. Along with air, acetic chloride may form an explosive mixture. It is incompatible with water, alcohols, amines, strong bases, strong oxidising agents, and most common metals. On decomposition when heated, acetic chloride produces carbon monoxide, carbon dioxide, hydrogen chloride, and phosgene.

Description

Acetyl chloride is a simple acyl halide commonly used to introduce acetyl groups onto amine or alcohol functionalities of substrates. Acetyl groups are sometimes used as protecting groups for amines. A common alternative to acetyl chloride for acetylation reactions is acetic anhydride.

The Uses of Acetyl chloride

Acetyl chloride acts as a reagent for the preparation of esters and amides of acetic acid. It is also useful an important reactant in Friedel-Crafts reactions as well as the introduction of an acetyl group. It serves as a starting material in the production of pharmaceutical, new plating complexing agent, acylation agent and synthetic organic intermediates.

The Uses of Acetyl chloride

To a mixture of the SM (65 mg, 0.22 mmol) and TEA (67 mg, 0.66 mmol) in THF (5 mL) was added acetyl chloride (34 mg, 0.44 mmol) at RT. The reaction mixture was stirred at RT for 3 h. After concentration, the residue was purified by Prep HPLC to provide the product as a white solid. [52 mg, 70%]

What are the applications of Application

Acetyl chloride is an acid chloride reagent used for acetylation