Acetamide, N-[4-[7-cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]-

CAS NO.：2143072-85-7
Empirical Formula: C23H22N4O2
Molecular Weight: 386.45
Update Date: 2026-07-16 07:06:08

What is Acetamide, N-[4-[7-cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]-?

Description

RAGE 229 is an antagonist of the interaction between the cytoplasmic tail of the receptor for advanced glycation end products (ctRAGE) and the formin, Diaphanous-1 (DIAPH1) (KD for binding to ctRAGE = 2 nM). RAGE 229 inhibits the migration of human aortic smooth muscle cells in an in vitro wound healing assay (IC50 = 120 nM). RAGE 229 reduces short- and long-term complications of diabetes in mouse models, without lowering blood glucose concentrations. RAGE 229 also reduces plasma concentrations of TNF-α, IL-6, and CCL2/JE-MCP1 and attenuates inflammatory signaling in diabetic mice.

Storage

Store at -20°C

Properties of Acetamide, N-[4-[7-cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]-

Boiling point:	642.7±55.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
solubility	DMSO:38.65(Max Conc. mg/mL);100.0(Max Conc. mM)
pka	14.58±0.70(Predicted)
form	Solid
color	White to off-white

Safety information for Acetamide, N-[4-[7-cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]-

Computed Descriptors for Acetamide, N-[4-[7-cyano-4-(4-morpholinylmethyl)-2-quinolinyl]phenyl]-

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