N-(p-amylcinnamoyl) Anthranilic Acid
Synonym(s):2-[[1-oxo-3-(4-Pentylphenyl)-2-propen-1-yl]amino]-benzoic acid;ACA;N-(4-Pentylcinnamoyl)anthranilic acid
- CAS NO.：110683-10-8
- Empirical Formula: C21H23NO3
- Molecular Weight: 337.41
- MDL number: MFCD00211365
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:10
What is N-(p-amylcinnamoyl) Anthranilic Acid?
The Uses of N-(p-amylcinnamoyl) Anthranilic Acid
N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.
What are the applications of Application
N-(p-Amylcinnamoyl) anthranilic Acid (ACA) is a TRP channel modulator and PLA2 inhibitor
Definition
ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.
References
harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.
Properties of N-(p-amylcinnamoyl) Anthranilic Acid
| Melting point: | 172-174℃ |
| Boiling point: | 563.1±50.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | White solid. |
| pka | 3.49±0.36(Predicted) |
| color | White to Off-White |
Safety information for N-(p-amylcinnamoyl) Anthranilic Acid
| Signal word | Warning |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P403:Store in a well-ventilated place. |
Computed Descriptors for N-(p-amylcinnamoyl) Anthranilic Acid
New Products
Pentadecanoic acid 3-Bromophenylacetic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-Bromo-5-cyanopyridine 2-Amino-5-cyanopyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 3′-Hydroxyacetophenone 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide 1-(3-Hydroxyphenyl)-2-thiourea 4-Nitrobenzenesulfonohydrazide 2-Aminobenzo[d]thiazol-4-ol 4-Chloro-2-methyl quinoline 5,11-Dihydro-10H-dibenzo[b,f]azepin-10-one-1,2,3,4-d4 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile ethyl 1-(6-chloropyridin-2-yl)-5-hydroxy-1H-pyrazole-4-carboxylate N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride 2H-indol-2-one, 5-amino-1,3-dihydro-1-(1-methylethyl)-Related products of tetrahydrofuran
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