2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
Synonym(s):2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid;4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid
- CAS NO.：99754-06-0
- Empirical Formula: C21H22ClNO3
- Molecular Weight: 371.86
- MDL number: MFCD00210755
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:58
What is 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID?
Description
ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5
The Uses of 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor.
What are the applications of Application
ONO-RS-082 is a potent PLA2 and epinephrine inhibitor
in vitro
previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].
References
1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197 2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361 3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530 4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004 5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507
Properties of 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
| Melting point: | 175-177℃ |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | white |
| Sensitive | Light Sensitive |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
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