U-73343

Synonym(s):1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione;1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione;U-73343 - CAS 142878-12-4 - Calbiochem

CAS NO.：142878-12-4
Empirical Formula: C29H42N2O3
Molecular Weight: 466.66
MDL number: MFCD00211221
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is U-73343?

Description

U-73343 (142878-12-4) is a negative control for phospholipase C inhibitor U-73122 (Cat.# 10-1061).1,2 Elicits unexpected effects on rabbit parietal cells.3?Cell permeable.

The Uses of U-73343

U-73343 is an inactive structural analog of U-73122.

What are the applications of Application

U-73343 is an inactive structural analog of U-73122

General Description

A cell-permeable analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.

Biochem/physiol Actions

Cell permeable: yes

Storage

Store at RT

References

1) Bleasdale?et al. (1990),?Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther.,?255?756 2) Morley?et al. (1992),?A new, nongenomic estrogen action: the rapid release of intracellular calcium; Endocrinology,131?1305 3) Muto?et al. (1997),?The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell; J. Pharmacol. Exp. Ther.,?282?1379

Properties of U-73343

Boiling point:	641.5±55.0 °C(Predicted)
Density	1.15±0.1 g/cm3(Predicted)
storage temp.	+15C to +30C
solubility	ethanol: 0.93 mg/mL
form	powder
pka	10.68±0.40(Predicted)
color	white
Stability:	Stable for 1 year from date of purchase as supplied. Dried films prepared from chloroform solution are stable for at least 1 month at -20°. It is preferable to dissolve U-73343 immediately before use if at all possible. Use caution and retest potency if attempting.