U-73343
Synonym(s):1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione;1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione;U-73343 - CAS 142878-12-4 - Calbiochem
- CAS NO.：142878-12-4
- Empirical Formula: C29H42N2O3
- Molecular Weight: 466.66
- MDL number: MFCD00211221
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is U-73343?
Description
U-73343 (142878-12-4) is a negative control for phospholipase C inhibitor U-73122 (Cat.# 10-1061).1,2 Elicits unexpected effects on rabbit parietal cells.3?Cell permeable.
The Uses of U-73343
U-73343 is an inactive structural analog of U-73122.
What are the applications of Application
U-73343 is an inactive structural analog of U-73122
General Description
A cell-permeable analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.
Biochem/physiol Actions
Cell permeable: yes
Storage
Store at RT
References
1) Bleasdale?et al. (1990),?Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils; J. Pharmacol. Exp. Ther.,?255?756 2) Morley?et al. (1992),?A new, nongenomic estrogen action: the rapid release of intracellular calcium; Endocrinology,131?1305 3) Muto?et al. (1997),?The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell; J. Pharmacol. Exp. Ther.,?282?1379
Properties of U-73343
| Boiling point: | 641.5±55.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | +15C to +30C |
| solubility | ethanol: 0.93 mg/mL |
| form | powder |
| pka | 10.68±0.40(Predicted) |
| color | white |
| Stability: | Stable for 1 year from date of purchase as supplied. Dried films prepared from chloroform solution are stable for at least 1 month at -20°. It is preferable to dissolve U-73343 immediately before use if at all possible. Use caution and retest potency if attempting. |
Safety information for U-73343
Computed Descriptors for U-73343
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