AC2-12
Synonym(s):Annexin A1;Annexin I;ANX1;ANXA1;LPC1
- CAS NO.：256447-08-2
- Empirical Formula: C63H94N14O17S
- Molecular Weight: 1351.57
- MDL number: MFCD06411599
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-25 18:04:04
What is AC2-12?
Enzyme inhibitor
This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.
Properties of AC2-12
| storage temp. | -20°C |
| form | Solid |
| color | White to off-white |
| Water Solubility | Soluble to 1 mg/ml in 20% acetonitrile / Water |
Safety information for AC2-12
Computed Descriptors for AC2-12
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