AC2-12
Synonym(s):Annexin A1;Annexin I;ANX1;ANXA1;LPC1
- CAS NO.：256447-08-2
- Empirical Formula: C63H94N14O17S
- Molecular Weight: 1351.57
- MDL number: MFCD06411599
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-18 09:53:09
What is AC2-12?
Enzyme inhibitor
This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.
Properties of AC2-12
| storage temp. | -20°C |
| form | Solid |
| color | White to off-white |
| Water Solubility | Soluble to 1 mg/ml in 20% acetonitrile / Water |
Safety information for AC2-12
Computed Descriptors for AC2-12
New Products
tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Boc-Arg-OH HCl H2O Indole Methyl Resin 2-CTC Resin Gabapentin EP Impurity A 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidamide 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 1,3-Diphenylurea 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID N-METHYL INDAZOLE-3-CARBOXYLIC ACID 2-Hydroxy-5-nitroacetophenone 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,4-dihydroxybenzaldehyde 1,3-Diethyl-1,3-Diphenylurea 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2-HYDROXY BENZYL CYANIDE DIETHYL AMINOMALONATE HYDROCHLORIDE 5-BROMO-2CYANO PYRIDINE Boldenone Clarithromycin Ethinyl Estradiol StanozololRelated products of tetrahydrofuran
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