AC-IETD-AFC
- CAS NO.：211990-57-7
- Empirical Formula: C31H38F3N5O12
- Molecular Weight: 729.65
- MDL number: MFCD02094703
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:12
What is AC-IETD-AFC?
The Uses of AC-IETD-AFC
Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.
The Uses of AC-IETD-AFC
N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.
What are the applications of Application
Ac-IETD-AFC is a substrate for caspase-8/caspase-3 processing enzyme and granzyme B
Properties of AC-IETD-AFC
| Boiling point: | 1113.8±65.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO |
| form | Lyophilized powder |
| pka | 4.09±0.10(Predicted) |
| color | White to off-white |
Safety information for AC-IETD-AFC
Computed Descriptors for AC-IETD-AFC
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