ABD459
- CAS NO.：1047670-51-8
- Empirical Formula: C24H17BrCl2N2O2
- Molecular Weight: 516.21
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-18 09:51:29
What is ABD459?
Description
ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep.
Properties of ABD459
| Boiling point: | 615.6±55.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 3 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml |
| form | A crystalline solid |
| pka | -3.35±0.10(Predicted) |
Safety information for ABD459
Computed Descriptors for ABD459
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