Abacavir Carboxylate
- CAS NO.：384380-52-3
- Empirical Formula: C14H16N6O2
- Molecular Weight: 300.32
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is Abacavir Carboxylate?
Description
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.
Chemical properties
Off-White Solid
The Uses of Abacavir Carboxylate
Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3).
What are the applications of Application
Abacavir Carboxylate is a nucleoside reverse transcriptase inhibitor (NRTI)
Definition
ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir.
Properties of Abacavir Carboxylate
| Melting point: | 208-210°C (dec.) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| form | Solid |
| color | Off-White to Pale Beige |
| Stability: | Hygroscopic |
Safety information for Abacavir Carboxylate
Computed Descriptors for Abacavir Carboxylate
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