Abacavir 5’-β-D-Glucuronide Sodium Salt

Molecular Weight: 0
Update Date: 2023-04-23 13:52:06

What is Abacavir 5’-β-D-Glucuronide Sodium Salt?

The Uses of Abacavir 5’-β-D-Glucuronide Sodium Salt

Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Properties of Abacavir 5’-β-D-Glucuronide Sodium Salt

Melting point:	>206°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
color	Pale Beige
Stability:	Hygroscopic

Safety information for Abacavir 5’-β-D-Glucuronide Sodium Salt

Computed Descriptors for Abacavir 5’-β-D-Glucuronide Sodium Salt

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