(9S)-9-Amino-9-deoxoerythromycin

CAS NO.：26116-56-3
Empirical Formula: C37H70N2O12
Molecular Weight: 734.96
MDL number: MFCD00872156
EINECS: 406-790-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-16 09:56:27

What is (9S)-9-Amino-9-deoxoerythromycin?

Chemical properties

(9S)-9-Amino-9-deoxoerythromycin is White Solid

The Uses of (9S)-9-Amino-9-deoxoerythromycin

(9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

The Uses of (9S)-9-Amino-9-deoxoerythromycin

Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

The Uses of (9S)-9-Amino-9-deoxoerythromycin

(9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic

What are the applications of Application

Erythromycylamine is a semi-synthetic analogue of erythromycin, a potent antibiotic

Definition

ChEBI: A macrolide antibiotic that is erythromycin A in which the ketone group has been converted to the corresponding imine and then reduced to give the corresponding amino compound (the 9S diastereoisomer).

Properties of (9S)-9-Amino-9-deoxoerythromycin

Melting point:	123-127°C
Boiling point:	810.3±65.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	A solid
pka	13.41±0.70(Predicted)
color	White to off-white