9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- CAS NO.：981-34-0
- Empirical Formula: C22H28O5
- Molecular Weight: 372.45
- MDL number: MFCD09038712
- EINECS: 213-563-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:11
What is 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione ?
Description
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.
Chemical properties
Off-White Solid
The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Metabolite of Beclometasone (131000)
The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.
What are the applications of Application
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Beclometasone
Preparation
Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
Properties of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
| Melting point: | 210-220 ºC |
| Boiling point: | 564.9±50.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| vapor pressure | 0-357.304Pa at 25℃ |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated) |
| form | Solid |
| pka | 12.56±0.70(Predicted) |
| color | White to Light Beige |
Safety information for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Computed Descriptors for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
| InChIKey | GBDXNHBVYAMODG-OBDZOPJXNA-N |
| SMILES | C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r| |
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