9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

CAS NO.：1124329-14-1
Empirical Formula: C24H32N6O3
Molecular Weight: 452.55
MDL number: MFCD18384959
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:23:02

What is 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one?

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

The Uses of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

AZ 3146 is a protein kinase Mps1 inhibitor.

What are the applications of Application

AZ 3146 is a potent and selective TTK (monopolar spindle 1 (Mps1) kinase) inhibitor

Storage

Store at +4°C

References

1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309

Properties of 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Boiling point:	621.0±65.0 °C(Predicted)
Density	1.279
storage temp.	Store at +4°C
solubility	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form	solid
pka	8.29±0.10(Predicted)
color	Off-white
Stability:	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety information for 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Computed Descriptors for 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

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