9-(BETA-D-ARABINOFURANOSYL)GUANINE

Synonym(s):9-β-D-Arabinofuranosyl guanine hydrate

CAS NO.：38819-10-2
Empirical Formula: C10H13N5O5
Molecular Weight: 283.24
MDL number: MFCD00065486
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

9-(BETA-D-ARABINOFURANOSYL)GUANINE Structural

What is 9-(BETA-D-ARABINOFURANOSYL)GUANINE?

Description

Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine . Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA. Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts. It also halts the cell cycle at the sub-G₁ phase and induces apoptosis in CEM cells. Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.

The Uses of 9-(BETA-D-ARABINOFURANOSYL)GUANINE

Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic.

What are the applications of Application

Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic

Definition

ChEBI: A purine nucleoside in which guanine is attached to arabinofuranose via a beta-N9-glycosidic bond. It inhibits DNA synthesis and causes cell death.

Properties of 9-(BETA-D-ARABINOFURANOSYL)GUANINE

Melting point:	225°C(lit.)
Density	2.25±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: >10mg/mL
form	solid
pka	9?+-.0.20(Predicted)
color	White to Off-White
λmax	252nm(lit.)

Safety information for 9-(BETA-D-ARABINOFURANOSYL)GUANINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.