8-Methylquinoline

Synonym(s):o-Toluquinoline

CAS NO.：611-32-5
Empirical Formula: C10H9N
Molecular Weight: 143.19
MDL number: MFCD00006810
EINECS: 210-264-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 8-Methylquinoline?

Chemical properties

clear yellow liquid

The Uses of 8-Methylquinoline

8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.

The Uses of 8-Methylquinoline

8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.

Definition

ChEBI: A methylquinoline carrying a methyl substituent at position 8.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 1514, 1980 DOI: 10.1021/jo01296a035

General Description

Yellow liquid or oil.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

8-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

8-Methylquinoline is combustible.

Purification Methods

Purify it as for 2-methylquinoline. The phosphate and picrate have m 158o and m 201o, respectively. [Beilstein 20 III/IV 3500, 20/7 V 405.]

Properties of 8-Methylquinoline

Melting point:	-80 °C
Boiling point:	245 °C
Density	1.052 g/mL at 25 °C(lit.)
refractive index	n20/D 1.614(lit.)
Flash point:	221 °F
storage temp.	Room Temperature
solubility	Chloroform, Methanol
form	Liquid
pka	5.03±0.17(Predicted)
color	Clear yellow
Specific Gravity	1.052
Water Solubility	0.1-0.5 g/100 mL at 17 ºC
BRN	111340
CAS DataBase Reference	611-32-5(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 8-methyl-(611-32-5)
EPA Substance Registry System	8-Methylquinoline (611-32-5)

Safety information for 8-Methylquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.