HYDROXYFASUDIL MONOHYDROCHLORIDE

Chemical properties

Off-White Solid

The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated ( ROCK) contraction both in vitro and in vivo. A

The Uses of HYDROXYFASUDIL MONOHYDROCHLORIDE

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.

What are the applications of Application

Hydroxyfasudil Hydrochloride is a cell permeable metabolite of HA 1077

General Description

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC₅₀ = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

Storage

-20°C