8-hydroxyloxapine
- CAS NO.：61443-77-4
- Empirical Formula: C18H18ClN3O2
- Molecular Weight: 343.81
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is 8-hydroxyloxapine?
Description
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Chemical properties
Pale Yellow Solid
The Uses of 8-hydroxyloxapine
The inactive
What are the applications of Application
8-Hydroxy Loxapine is an inactive metabolite of Loxapine
Properties of 8-hydroxyloxapine
| Melting point: | 212-215°C |
| storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO: soluble |
| form | A solid |
| Stability: | Light Sensitive |
Safety information for 8-hydroxyloxapine
Computed Descriptors for 8-hydroxyloxapine
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline 5-Hydroxy-3,9-dimethyl-7H-benzo[c]fluoren-7-one Methyl 4-(acetyloxy)-6-methoxy-1-(4-methoxyphenyl)-2naphthalenecarboxylate 4-Hydroxy-6,7-dimethoxy-1-phenyl-2naphthalenecarboxylic acid (3,5-Dibromophenyl)[4-(trifluoromethyl)phenyl]methanone (4-butoxyphenyl)(4-fluorophenyl)methanone (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 4-Ethyl-4-hydroxy-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione (E)-N'-(2-cyano-4-nitrophenyl)- N,N-dimethylformimidamide 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid Benzyl-N,4-dimethylpiperidine-3- amine dihydrochloride 5-bromopyridin-2-amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3-chlorobenzyl cyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
You may like
-
151239-47-3 98+View Details
151239-47-3 -
4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 98+View Details
101894-09-1 -
83883-25-4 98+View Details
83883-25-4 -
(3,5-dibromophenyl)(4-methoxyphenyl)methanone 1991533-97-1 98+View Details
1991533-97-1 -
329786-30-3 98+View Details
329786-30-3 -
54598-15-1 4,5,7-Trimethyl-2(1H)-quinolinone 98+View Details
54598-15-1 -
4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 83883-25-4 98+View Details
83883-25-4 -
2-[4-(1,1-Dimethylethyl)-2-naphthalenyl]-4,4,5,5tetramethyl-1,3,2-dioxaborolane 98+View Details
2217657-10-6