8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
Synonym(s):8-Br-cAMP;8-Bromo-cAMP, Na;Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem
- CAS NO.：76939-46-3
- Empirical Formula: C10H12BrN5NaO6P
- Molecular Weight: 432.1
- MDL number: MFCD00005844
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT?
Chemical properties
Off-white powder
The Uses of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:
- to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
- used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
- in superfusion medium for head kidneys stimulation
What are the applications of Application
8-Bromo-cAMP is a cell-permeable cyclic AMP (cAMP) analog that preferentially activates cAMP-dependent PKA.
General Description
8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.
Biological Activity
Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™ .
Biochem/physiol Actions
Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.
Storage
-20°C (desiccate)
Properties of 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
| Melting point: | >264°C )dec._ |
| storage temp. | -20°C |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | off-white |
| Water Solubility | Soluble in water (100mM) |
| BRN | 7739743 |
| Stability: | Hygroscopic, Moisture Sensitive |
Safety information for 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
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