7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS NO.：73942-87-7
- Empirical Formula: C12H13NO3
- Molecular Weight: 219.24
- MDL number: MFCD02091565
- EINECS: 456-160-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-23 14:48:42
What is 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one?
The Uses of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
What are the applications of Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
Properties of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
| Melting point: | 244.0 to 248.0 °C |
| Boiling point: | 455.8±45.0 °C(Predicted) |
| Density | 1.167 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 13.29±0.20(Predicted) |
| color | Off-White to Pale Beige |
| CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
Safety information for 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Computed Descriptors for 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturer
Aditya Molecules
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride](https://img.chemicalbook.in/CAS/GIF/866783-13-3.gif)
You may like
-
73942-87-7 98%View Details
73942-87-7 -
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 99%View Details -
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 98%View Details
73942-87-7 -
73942-87-7 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 98%View Details
73942-87-7 -
73942-87-7 98%View Details
73942-87-7 -
![7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one CAS 73942-87-7](https://img.chemicalbook.in//Content/image/CP5.jpg)
7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one CAS 73942-87-7View Details
73942-87-7 -
7,8-Dimethoxy-1,3-Dihydro-2H-3-Benzazepin-2-OneView Details
73942-87-7 -
99.9 Min Powder 7,8-Dimethoxy-1,3-Dihydro-2h-3-Benzazepin-2-One (CAS No.: 73942-87-7)View Details
73942-87-7