7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS NO.：73942-87-7
- Empirical Formula: C12H13NO3
- Molecular Weight: 219.24
- MDL number: MFCD02091565
- EINECS: 456-160-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one?
The Uses of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.
What are the applications of Application
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.
Definition
ChEBI: 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one is a benzazepine.
Synthesis
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.
2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
Properties of 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
| Melting point: | 244.0 to 248.0 °C |
| Boiling point: | 455.8±45.0 °C(Predicted) |
| Density | 1.167 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 13.29±0.20(Predicted) |
| color | Off-White to Pale Beige |
| CAS DataBase Reference | 73942-87-7(CAS DataBase Reference) |
Safety information for 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Computed Descriptors for 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one manufacturer
Coastal drugs
Aditya Molecules
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