7-Nitroindazole
Synonym(s):7-NI
- CAS NO.：2942-42-9
- Empirical Formula: C7H5N3O2
- Molecular Weight: 163.13
- MDL number: MFCD00022789
- EINECS: 220-934-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 7-Nitroindazole?
Description
7-
Chemical properties
yellow powder or Yellow orange solid soluble in DMSO.
The Uses of 7-Nitroindazole
7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.
What are the applications of Application
7-Nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS)
Definition
7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).
Biological Activity
Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole).
Properties of 7-Nitroindazole
| Melting point: | 185-186°C |
| Boiling point: | 290.19°C (rough estimate) |
| Density | 1.4141 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| form | powder to crystal |
| pka | 10.03±0.40(Predicted) |
| color | Light yellow to Brown |
| Water Solubility | slightly soluble |
| BRN | 6809 |
| InChI | InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) |
| CAS DataBase Reference | 2942-42-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 7-Nitroindazole(2942-42-9) |
Safety information for 7-Nitroindazole
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H319:Serious eye damage/eye irritation H351:Carcinogenicity H360:Reproductive toxicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 7-Nitroindazole
| InChIKey | PQCAUHUKTBHUSA-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2[N+]([O-])=O)C=N1 |
7-Nitroindazole manufacturer
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