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HomeProduct name list7-Nitroindazole

7-Nitroindazole

Synonym(s):7-NI

  • CAS NO.:2942-42-9
  • Empirical Formula: C7H5N3O2
  • Molecular Weight: 163.13
  • MDL number: MFCD00022789
  • EINECS: 220-934-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-15 15:12:15
7-Nitroindazole Structural

What is 7-Nitroindazole?

Description

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively.

The Uses of 7-Nitroindazole

7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.

What are the applications of Application

7-Nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS)

Properties of 7-Nitroindazole

Melting point: 185-186°C
Boiling point: 290.19°C (rough estimate)
Density  1.4141 (rough estimate)
storage temp.  -20°C
solubility  Soluble to 100 mM in DMSO and to 20 mM in ethanol
form  powder to crystal
color  Light yellow to Brown
Water Solubility  slightly soluble

Safety information for 7-Nitroindazole

Signal word Danger
Pictogram(s)

Skull and Crossbones
Acute Toxicity
GHS06

Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H319:Serious eye damage/eye irritation
H351:Carcinogenicity
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 7-Nitroindazole

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