6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

CAS NO.：134-47-4
Empirical Formula: C21H16N2O9S2
Molecular Weight: 504.49
MDL number: MFCD00035715
EINECS: 205-142-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 00:50:26

What is 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)?

The Uses of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (cas# 134-47-4) is a pharmacologically active compound capable of selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase, and inhibition of shikimate dehydrogenase and shikimate kinase in shikimate pathway of Helicobacter pylori.

What are the applications of Application

AMI-1, free acid is a chemical shown to inhibit arginine, in vitro, with no inhibitory effect on lysine

Preparation

7,7' -Urylenebis(4-hydroxynaphthalene-2- sulfonic acid) [134-47-4] , J acid urea, carbonyl J acid, is produced by reacting the sodium salt of J acid with phosgene in aqueous solution at 30℃ and maintaining alkalinity with sodium carbonate. After being heated to 80℃, the product is salted out with sodium chloride (yield ca. 100 %). It is used to produce C.I. Direct Orange 26; C.I. Direct Reds 4, 14, 23, and 80; and C.I. Direct Brown 112.

Properties of 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

Density	1.798±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: 83.33 mg/mL (165.18 mM)
pka	-0.17±0.40(Predicted)
form	Solid
color	Light brown to brown
CAS DataBase Reference	134-47-4(CAS DataBase Reference)
EPA Substance Registry System	7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] (134-47-4)

Safety information for 6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid)

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P285:In case of inadequate ventilation wear respiratory protection. P304+P341:IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. P403:Store in a well-ventilated place.