6-Nitroindoline
Synonym(s):6-Nitro-2,3-dihydroindole;NSC 80658
- CAS NO.：19727-83-4
- Empirical Formula: C8H8N2O2
- Molecular Weight: 164.16
- MDL number: MFCD00005710
- EINECS: 243-257-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:26
What is 6-Nitroindoline?
Chemical properties
orange crystalline powder or red crystals
The Uses of 6-Nitroindoline
• ;Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists1• ;Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents2• ;Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities3• ;Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists4• ;Reactant for preparation of antiarrhythmic benzopyrans5• ;Reactant for preparation of 5-HT2C/2B receptor antagonists6
The Uses of 6-Nitroindoline
- Reactant for preparation of 2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin analogs as novel MT2-selective melatonin receptor antagonists
- Reactant for synthesis of isoindigo and azaisoindigo glycosides as anticancer agents
- Reactant for preparation of arylfurancarboxamides with Nav1.8 voltage-gated Na channel blocking/analgesic activities
- Reactant for preparation of bicyclic benzamides as 5-HT1 receptor agonists
- Reactant for preparation of antiarrhythmic benzopyrans
- Reactant for preparation of 5-HT2C/2B receptor antagonists
Properties of 6-Nitroindoline
| Melting point: | 67-69 °C (lit.) |
| Boiling point: | 291.62°C (rough estimate) |
| Density | 1.2739 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.39±0.20(Predicted) |
| form | Crystalline Powder or Crystals |
| color | Orange or red |
| BRN | 156434 |
| CAS DataBase Reference | 19727-83-4(CAS DataBase Reference) |
Safety information for 6-Nitroindoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Nitroindoline
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