6-Methylpyrazine-2-carboxylic acid

The Uses of 6-Methylpyrazine-2-carboxylic acid

6-METHYLPYRAZINE-2-CARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

The Uses of 6-Methylpyrazine-2-carboxylic acid

6-Methylpyrazinecarboxylic Acid can be used to synthesize compounds that are active against M.tuberculosis H37Rv. Similarly, it can be used to synthesize compounds that are useful for the inhibition, prevention or therapy of tumor cell invasion, metastasis, inflammation, hepatitis, or liver dysfunction.

Synthesis

2,6-Dimethylpyrazine (500mg, 4.60mmol) was dissolved in water (10ml), heated at 700C and KMnO4 in water (25ml) was added dropwise. The mixture was stirred and heated overnight. After cooling to room temperature the MnO2 cake was filtered and washed with water several times. The filtrate was acidified with 5M HCI solution (pH 1.5) and extracted with ethyl acetate (3 x 50ml). The residue was dried over magnesium sulphate, filtered and evaporated to afford the product (D25); MS (ES+) m/e 139 [M+H]+.