6-Hydroxycoumarin
- CAS NO.：6093-68-1
- Empirical Formula: C9H6O3
- Molecular Weight: 162.14
- MDL number: MFCD00630040
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is 6-Hydroxycoumarin?
Description
6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.
Occurrence
6-Hydroxycoumarin is a natural product found in Grevillea robusta and Amburana cearensis with data available.
The Uses of 6-Hydroxycoumarin
6-Hydroxycoumarin (cas# 6093-68-1) is a compound useful in organic synthesis.
Preparation
(1) synthesis of 6-aminocoumarins：In polar solvent, using 6- nitroscumarin as raw material, using hydrazine hydrate as hydrogen Source, is reducing catalyst using ferric chloride (FeCl36H2O), at ambient pressure reduces 6-nitroscumarin, prepare 6- aminocoumarins；
(2) synthesis of 6-Hydroxycoumarins：In sulfuric acid solution, one-step method is by 6-aminocoumarins after diazo-reaction Direct hydrolysis, prepares 6-Hydroxycoumarins in high yield.
The preparation method of 6 Hydroxycoumarins
Properties of 6-Hydroxycoumarin
| Melting point: | 249-253 °C (lit.) |
| Boiling point: | 248.82°C (rough estimate) |
| Density | 1.2500 |
| refractive index | 1.5380 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 8.92±0.20(Predicted) |
| form | Solid |
| color | White to yellow |
| λmax | 349nm(EtOH)(lit.) |
| CAS DataBase Reference | 6093-68-1(CAS DataBase Reference) |
Safety information for 6-Hydroxycoumarin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Hydroxycoumarin
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