6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
- CAS NO.：328956-08-7
- Empirical Formula: C10H5F4NO
- Molecular Weight: 231.15
- MDL number: MFCD17015723
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:52:08
What is 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone?
Chemical properties
White solid
Description
As a quinoline derivative, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is substituted with trifluoromethyl, hydroxyl, and fluoride groups. In particular, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline can exist in a tautomeric form, known as quinolone, where the hydroxy group becomes a ketone and the imine changes to an amine. This compound is a precursor for synthesizing thioquinolines, which are used to develop non-cytotoxic, potent and selective antitubercular agents. The thiolation reaction is carried out using phosphorus pentasulfide in pyridine.
Properties of 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
| Melting point: | 252-253 °C (decomp)(Solv: ethanol (64-17-5)) |
| Boiling point: | 282 ºC |
| Density | 1.468 |
| Flash point: | 124 ºC |
| storage temp. | 2-8°C |
| pka | 9.33±0.70(Predicted) |
| InChI | InChI=1S/C10H5F4NO/c11-5-1-2-8-6(3-5)7(10(12,13)14)4-9(16)15-8/h1-4H,(H,15,16) |
Safety information for 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
Computed Descriptors for 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
| InChIKey | WUFRBOSKPZUGIS-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(F)C=C2)C(C(F)(F)F)=CC1=O |
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