6-Cyano-2-naphthol
Synonym(s):6-Hydroxy-2-naphthonitrile;2-Cyano-6-hydroxynaphthalene;2-Cyano-6-naphthol;2-Hydroxy-6-naphthonitrile;6-Cyano-2-hydroxynaphthalene
- CAS NO.：52927-22-7
- Empirical Formula: C11H7NO
- Molecular Weight: 169.18
- MDL number: MFCD01863480
- EINECS: 628-663-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-05 19:35:02
What is 6-Cyano-2-naphthol?
Chemical properties
Brown Crystalline Solid. 6-Cyano-b-naphthol [52927-22-7], 6-cyano2-hydroxynaphthalene, 6-hydroxy-2-naphthoic acid nitrile, Mr 169.17, mp 166 – 167℃ This nitrile is used as an intermediate for the production of liquid crystals and monoamino-oxidase-inhibiting naphthalene-2-oxyalkylamines, which are used as antidepressive agents.
The Uses of 6-Cyano-2-naphthol
Intermediate of Nafamostat mesilate (N210000).
The Uses of 6-Cyano-2-naphthol
Reactant for:
- Palladium-catalyzed reduction
- Nickel-catalyzed cross-coupling reactions
- Palladium-catalyzed Heck reactions
What are the applications of Application
6-Cyano-2-naphthol is An intermediate of Nafamostat mesilate
General Description
6-Cyano-2-naphthol (6CN2) is an aromatic alcohol that can be synthesized from 6-bromo-2-naphthol. It is a superphotoacid with the ground state pKa* value of 8.4 and excited state pKavalue of 0.2, respectively. 6CN2 protonates PANI-ES (polyaniline emeraldine salt) to form PANI-EB (emeraldine base), which shows enhanced conductivity. The proton-transfer kinetics and photophysical behavior of 6CN2 have been investigated.
Properties of 6-Cyano-2-naphthol
| Melting point: | 165.5-170.5 °C (lit.) |
| Boiling point: | 383.1±15.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethanol, Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.57±0.40(Predicted) |
| color | Pale Brown to Brown |
| CAS DataBase Reference | 52927-22-7(CAS DataBase Reference) |
Safety information for 6-Cyano-2-naphthol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Cyano-2-naphthol
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