6-Chlorouracil

Synonym(s):4-Chloro-2,6-dihydroxypyrimidine;6-Chloro-2,4-dihydroxypyrimidine;6-Chlorouracil

CAS NO.：4270-27-3
Empirical Formula: C4H3ClN2O2
Molecular Weight: 146.53
MDL number: MFCD00014595
EINECS: 224-258-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:12:47

What is 6-Chlorouracil?

Chemical properties

White to off-white powder

The Uses of 6-Chlorouracil

6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases.

The Uses of 6-Chlorouracil

Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

Properties of 6-Chlorouracil

Melting point:	290-295°C
Boiling point:	300°C
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Ammonium Hydroxide
form	Solid
pka	6.24±0.10(Predicted)
color	White
Water Solubility	4.885g/L(25 ºC)
BRN	120492
InChI	InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9)
CAS DataBase Reference	4270-27-3(CAS DataBase Reference)
NIST Chemistry Reference	6-Chlorouracil(4270-27-3)

Safety information for 6-Chlorouracil

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.