6-Chlorouracil
Synonym(s):4-Chloro-2,6-dihydroxypyrimidine;6-Chloro-2,4-dihydroxypyrimidine;6-Chlorouracil
- CAS NO.：4270-27-3
- Empirical Formula: C4H3ClN2O2
- Molecular Weight: 146.53
- MDL number: MFCD00014595
- EINECS: 224-258-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:13
What is 6-Chlorouracil?
Chemical properties
White to off-white powder
The Uses of 6-Chlorouracil
6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases.
The Uses of 6-Chlorouracil
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.
Properties of 6-Chlorouracil
| Melting point: | 290-295°C |
| Boiling point: | 300°C |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in Ammonium Hydroxide |
| form | Solid |
| pka | 6.24±0.10(Predicted) |
| color | White |
| Water Solubility | 4.885g/L(25 ºC) |
| BRN | 120492 |
| InChI | InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9) |
| CAS DataBase Reference | 4270-27-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 6-Chlorouracil(4270-27-3) |
Safety information for 6-Chlorouracil
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Chlorouracil
| InChIKey | PKUFNWPSFCOSLU-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(Cl)=CC(=O)N1 |
6-Chlorouracil manufacturer
PRODEV PHARMA (OPC) PRIVATE LIMITED
2Y
Phone:+919849892844
Whatsapp: +91-9849892844
product: 4270-27-3 98%
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