6-Aminoindole
Synonym(s):Indol-6-ylamine;NSC 82379
- CAS NO.：5318-27-4
- Empirical Formula: C8H8N2
- Molecular Weight: 132.16
- MDL number: MFCD02093959
- EINECS: 627-713-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:01
What is 6-Aminoindole?
Chemical properties
Solid
The Uses of 6-Aminoindole
Reactant for preparation of:
- Inhibitors of mammalian target of rapamycin (mTOR ) protein
- Inhibitors of the AcrAB-TolC efflux pump
- Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
- Potent DNA-topoisomerase II poisons and anti-MDR agents
- Protein kinase C θ (PKCθ) inhibitors
- Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists
- Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain
- 5,6-fused heteroaromatic ureas as TRPV1 antagonists
- Allosteric enhancers of the A3 adenosine receptor
- Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 diabetes
Properties of 6-Aminoindole
| Melting point: | 75-79 °C |
| Boiling point: | 161-166°C 2mm |
| Density | 1.268±0.06 g/cm3(Predicted) |
| Flash point: | 161-166°C/2mm |
| storage temp. | -20°C |
| solubility | soluble in Methanol |
| form | Crystalline Powder |
| pka | 18.23±0.30(Predicted) |
| color | White to brown |
| Sensitive | Air Sensitive |
| BRN | 112190 |
| CAS DataBase Reference | 5318-27-4(CAS DataBase Reference) |
Safety information for 6-Aminoindole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Aminoindole
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