6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE

Synonym(s):4-Amino-5-bromo-2-hydroxypyrimidine

CAS NO.：2240-25-7
Empirical Formula: C4H4BrN3O
Molecular Weight: 190
MDL number: MFCD00056025
EINECS: 218-806-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-05 08:34:14

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Structural

What is 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE?

Chemical properties

LIGHT YELLOW AMORPHOUS POWDER

The Uses of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE

4-Amino-5-bromo-2-hydroxypyrimidine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.

The Uses of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE

5-Bromocytosine was used in the synthesis of five cross-link products- C[5-N6]A, C[5-2]A, C[5-8]A, A[2-5]C, and A[8-5]C, under both aerobic and anaerobic conditions.

What are the applications of Application

5-Bromocytosine is a potent anti-HIV agent

General Description

5-Bromocytosine derivative (β isomer) is a potent anti-HIV agent.

Purification Methods

5-Bromocytosine is recrystallised from H2O or 50% aqueous EtOH. Alternatively, dissolve ca 3g in conc HCl (10mL) and evaporate to dryness. Dissolve the residual hydrochloride in the minimum volume of warm H2O and make faintly alkaline with aqueous NH3. Collect the crystals and dry them in a vacuum at 100o. [Hilbdert & Jensen J Am Chem Soc 56 134 1934, Beilstein 25 III/IV 3689.]

Properties of 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE

Melting point:	240-243 °C (dec.) (lit.)
Density	1.7513 (rough estimate)
refractive index	1.6520 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in formic acid (50 mg/ml).
form	Solid
pka	7.34±0.10(Predicted)
color	White to yellow
BRN	127286
NIST Chemistry Reference	5-Bromocytosine(2240-25-7)

Safety information for 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.