5,8,11-EICOSATRIYNOIC ACID
- CAS NO.：13488-22-7
- Empirical Formula: C20H28O2
- Molecular Weight: 300.44
- MDL number: MFCD00077343
- EINECS: 200-533-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-24 18:26:40
What is 5,8,11-EICOSATRIYNOIC ACID?
The Uses of 5,8,11-EICOSATRIYNOIC ACID
ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.
What are the applications of Application
ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor
Definition
ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions.
Biological Activity
5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2].
References
[1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6.
Properties of 5,8,11-EICOSATRIYNOIC ACID
| Melting point: | 70.5-71.5 °C |
| Boiling point: | 473.8±40.0 °C(Predicted) |
| Density | 0.990±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Off-white solid. |
| pka | 4.61±0.10(Predicted) |
| color | Pale Yellow to Pale Beige |
| Stability: | Light Sensitive |
Safety information for 5,8,11-EICOSATRIYNOIC ACID
Computed Descriptors for 5,8,11-EICOSATRIYNOIC ACID
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