5-(piperazin-1-yl)pyridin-2-aMine

CAS NO.：1082876-26-3
Empirical Formula: C9H14N4
Molecular Weight: 178.23
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:35:46

What is 5-(piperazin-1-yl)pyridin-2-aMine?

The Uses of 5-(piperazin-1-yl)pyridin-2-aMine

5-?(1-?Piperazinyl)?-?2-?pyridinamine is a reagent used in the synthesis of anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

Properties of 5-(piperazin-1-yl)pyridin-2-aMine

Boiling point:	401.7±40.0 °C(Predicted)
Density	1.163±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8.67±0.10(Predicted)
color	Pale Brown to Light Brown

Safety information for 5-(piperazin-1-yl)pyridin-2-aMine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.