5-Nonanone

Chemical properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Chemical properties

5-Nonanone is a stable and colorless-to-light yellow liquid.
No human odor threshold was identified for 5-nonanone. However, Laska et al. demonstrated using a conditioning paradigm that the olfactory threshold of squirrel monkeys and pigtail caques for 5-nonanone is below 1 ppb .

The Uses of 5-Nonanone

5-Nonanone is used in preparation of 6-(1,2,4-oxadiazol-5-yl)chroman-4-one derivatives as S1P1 receptor modulators and methods for preparing them.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 2738, 1967 DOI: 10.1021/ja00987a043
The Journal of Organic Chemistry, 52, p. 5570, 1987 DOI: 10.1021/jo00234a012
Tetrahedron Letters, 7, p. 6145, 1966

General Description

Colorless to light yellow liquid. Floats on water. Freezing point is 21°F.

Air & Water Reactions

Highly flammable.

Reactivity Profile

Ketones, such as 5-Nonanone, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. May attack some forms of plastics [USCG, 1999].

Health Hazard

Inhalation causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes or skin causes irritation.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Biochem/physiol Actions

5-Nonanone induces clinical neuropathy in rats.