5-Methyltetrahydrofolic acid

CAS NO.：134-35-0
Empirical Formula: C20H25N7O6
Molecular Weight: 459.46
MDL number: MFCD00900533
EINECS: 603-809-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-08 10:32:36

What is 5-Methyltetrahydrofolic acid?

Chemical properties

Off-White Solid

The Uses of 5-Methyltetrahydrofolic acid

5-Methyltetrahydrofolic acid is a metabolite of Folic acid; inhibits photosensitization reactions and strand breaks in DNA. 5-Methyltetrahydrofolic acid-(glutamic acid-13C5) can be used as a stable isotope internal standard for accurate data interpretation in citrus juice samples by LC-MS.

The Uses of 5-Methyltetrahydrofolic acid

5-Methyltetrahydrofolic acid-(glutamic acid-¹³C₅) can be used as a stable isotope internal standard for accurate data interpretation in citrus juice samples by LC-MS.

General Description

5-Methyltetrahydrofolic acid (5-MTHF) is an active folate metabolite. It plays an important role in the synthesis of methionine from homocysteine by donating methyl group.
5-Methyltetrahydrofolic acid-(glutamic acid-¹³C₅) is an isotope of vitamin B9 wherein all the five glutamate carbons are replaced by ¹³C₆ carbon.

Properties of 5-Methyltetrahydrofolic acid

Melting point:	>300°C (dec.)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Aqueous Base (Slightly, Sonicated)
form	Solid
pka	3.51±0.10(Predicted)
color	Pale Beige
Stability:	Hygroscopic

Safety information for 5-Methyltetrahydrofolic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.