5-Methoxysalicylic acid
Synonym(s):5-Methoxysalicylic acid
- CAS NO.：2612-02-4
- Empirical Formula: C8H8O4
- Molecular Weight: 168.15
- MDL number: MFCD00002459
- EINECS: 220-037-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 5-Methoxysalicylic acid?
Description
5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. It is a component of castoreum, the exudate from the castor sacs of the mature beaver.
A mixture of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry.
It is an isomer of vanillic acid.
2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Chemical properties
beige fine crystalline powder
The Uses of 5-Methoxysalicylic acid
5-Methoxysalicylic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
The Uses of 5-Methoxysalicylic acid
2-Hydroxy-5-methoxybenzoic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
Definition
ChEBI:5-methoxysalicylic acid is a methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5. It has a role as a bacterial metabolite and a human urinary metabolite.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 2301, 1950 DOI: 10.1021/ja01161a530
General Description
2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Properties of 5-Methoxysalicylic acid
| Melting point: | 141-143 °C(lit.) |
| Boiling point: | 217.07°C (rough estimate) |
| Density | 1.1816 (rough estimate) |
| refractive index | 1.4611 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Fine Crystalline Powder |
| pka | 3.01±0.10(Predicted) |
| color | Beige |
| Water Solubility | 1.7 g/L (10 ºC) |
| BRN | 2209647 |
| CAS DataBase Reference | 2612-02-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 2-hydroxy-5-methoxy- (2612-02-4) |
Safety information for 5-Methoxysalicylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Methoxysalicylic acid
| InChIKey | IZZIWIAOVZOBLF-UHFFFAOYSA-N |
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