5-Methoxyindole-3-acetonitrile
Synonym(s):3-(Cyanomethyl)-5-methoxyindole
- CAS NO.：2436-17-1
- Empirical Formula: C11H10N2O
- Molecular Weight: 186.21
- MDL number: MFCD02094163
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:30:22
What is 5-Methoxyindole-3-acetonitrile?
Chemical properties
Brown powder
The Uses of 5-Methoxyindole-3-acetonitrile
Reactant for preparation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors
Reactant for preparation of carboline analogs as potent MAPKAP-K2 inhibitors
Reactant for preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment
Reactant for preparation of debromoflustramine B and labeled Me(3a)-13C-physostigmine
Reactant for preparation of physostigmine and physovenine
Reactant for preparation of phenethyl substituted indole derivatives as melatoninergic agonists and antagonists
The Uses of 5-Methoxyindole-3-acetonitrile
5-Methoxyindole-3-acetonitrile is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors.
Properties of 5-Methoxyindole-3-acetonitrile
| Melting point: | 65-69 °C (lit.) |
| Boiling point: | 175-177 °C(Press: 0.01 Torr) |
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 16.02±0.30(Predicted) |
| color | Very Dark Brown |
| CAS DataBase Reference | 2436-17-1(CAS DataBase Reference) |
Safety information for 5-Methoxyindole-3-acetonitrile
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Methoxyindole-3-acetonitrile
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