5-Iodouracil
Synonym(s):2,4-Dihydroxy-5-iodopyrimidine
- CAS NO.：696-07-1
- Empirical Formula: C4H3IN2O2
- Molecular Weight: 237.98
- MDL number: MFCD00006020
- EINECS: 211-788-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 18:10:29
What is 5-Iodouracil?
Chemical properties
white to light yellow fluffy powder
The Uses of 5-Iodouracil
5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studie s show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
The Uses of 5-Iodouracil
5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
Definition
ChEBI: An organoiodine compound consisting of uracil having an iodo substituent at the 5-position.
Properties of 5-Iodouracil
| Melting point: | 274-276 °C (dec.) (lit.) |
| Density | 2.2076 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very faint turbidity in NH3aq. Soluble in 1M NaOH. |
| form | Fluffy Powder |
| pka | 7.02±0.10(Predicted) |
| color | White to light yellow |
| Water Solubility | SOLUBLE IN COLD WATER |
| Sensitive | Light Sensitive |
| BRN | 4891 |
| CAS DataBase Reference | 696-07-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Iodouracil(696-07-1) |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 5-iodo- (696-07-1) |
Safety information for 5-Iodouracil
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Iodouracil
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