5-Fluoroisatin
Synonym(s):5-Fluoro-2,3-indoledione;NSC 39161
- CAS NO.：443-69-6
- Empirical Formula: C8H4FNO2
- Molecular Weight: 165.12
- MDL number: MFCD00022795
- EINECS: 628-890-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is 5-Fluoroisatin ?
Chemical properties
5-Fluoroisatin is a red crystalline powder,contains a fluorine (5-position) and two carbonyls (2,3-positions). The carbonyl group at 3-position reacts with amines or hydrazines for imines or hydrazones that function as Schiff bases. The Schiff base based on 5-fluoroisatin coordinates to cobalt, yielding Co-isatin complexes.
The Uses of 5-Fluoroisatin
5-Fluoro isatin showed antibacterial and antifungal activities.
The Uses of 5-Fluoroisatin
Reactant for preparation of:
- Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
- Potential antimycobacterial agents
- Inhibitors of c-Met kinase
- Inhibitors of TAK1 kinase
- Herpes simplex virus inhibitors
- IKKβ inhibitors
- Inhibitors of vitiligo disease
- Potential drug candidates with anti-HIV activity and anti-tubercular activity
Definition
ChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.
General Description
5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).
5-Fluoro isatin applications
5-Fluoro isatin is a reactant for the preparation of many compounds.
Properties of 5-Fluoroisatin
| Melting point: | 224-227 °C (lit.) |
| Density | 1.477±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, DMSO, Methanol |
| form | Powder |
| pka | 8.51±0.20(Predicted) |
| color | Red |
| BRN | 131241 |
| CAS DataBase Reference | 443-69-6(CAS DataBase Reference) |
Safety information for 5-Fluoroisatin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Fluoroisatin
| InChIKey | GKODDAXOSGGARJ-UHFFFAOYSA-N |
5-Fluoroisatin manufacturer
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