5-Fluoroisatin

Chemical properties

5-Fluoroisatin is a red crystalline powder,contains a fluorine (5-position) and two carbonyls (2,3-positions). The carbonyl group at 3-position reacts with amines or hydrazines for imines or hydrazones that function as Schiff bases. The Schiff base based on 5-fluoroisatin coordinates to cobalt, yielding Co-isatin complexes.

The Uses of 5-Fluoroisatin

5-Fluoro isatin showed antibacterial and antifungal activities.

The Uses of 5-Fluoroisatin

Reactant for preparation of:

• Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
• Potential antimycobacterial agents
• Inhibitors of c-Met kinase
• Inhibitors of TAK1 kinase
• Herpes simplex virus inhibitors
• IKKβ inhibitors
• Inhibitors of vitiligo disease
• Potential drug candidates with anti-HIV activity and anti-tubercular activity

Definition

ChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.

General Description

5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).

5-Fluoro isatin applications

5-Fluoro isatin is a reactant for the preparation of many compounds.