5-Fluoro-2-picolinic acid

CAS NO.：107504-08-5
Empirical Formula: C6H4FNO2
Molecular Weight: 141.1
MDL number: MFCD04114196
EINECS: 675-772-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:11:55

What is 5-Fluoro-2-picolinic acid?

Synthesis

Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).

Properties of 5-Fluoro-2-picolinic acid

Melting point:	164-166℃
Boiling point:	275.1±20.0 °C(Predicted)
Density	1.419±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	3.58±0.10(Predicted)
color	White to Light yellow to Light orange
CAS DataBase Reference	107504-08-5(CAS DataBase Reference)

Safety information for 5-Fluoro-2-picolinic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.