5-FLUORO-1,3-DIMETHYLURACIL
Synonym(s):1,3-Dimethyl-5-fluorouracil;2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine
- CAS NO.：3013-92-1
- Empirical Formula: C6H7FN2O2
- Molecular Weight: 158.13
- MDL number: MFCD00192176
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-18 11:52:23
What is 5-FLUORO-1,3-DIMETHYLURACIL?
The Uses of 5-FLUORO-1,3-DIMETHYLURACIL
5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:
- Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
- To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
- To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.
Synthesis Reference(s)
Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3
General Description
Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution.
Properties of 5-FLUORO-1,3-DIMETHYLURACIL
| Melting point: | 132-134 °C(lit.) |
| Boiling point: | 182.5±50.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| pka | -4.07±0.40(Predicted) |
| BRN | 880396 |
Safety information for 5-FLUORO-1,3-DIMETHYLURACIL
Computed Descriptors for 5-FLUORO-1,3-DIMETHYLURACIL
New Products
2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide o-Anisaldehyde 4-Bromobenzaldehyde 3-Fluorobenzaldehyde 2-Chlorobenzaldehyde 3-Amino-3-(3-fluorophenyl)propanoic acid 1-Propyl-4-piperidone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 1-Boc-4-cyanopiperidine ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Vardenafil Bis-sulphonamide(Dimer) Nitroso Irbesartan N-Nitroso Nortriptyline Sulfonic acid Impurity 2-(p-Tolyl)acetaldehyde 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
![ETHYL [5-FLUORO-3-(4-METHOXY-3-NITROBENZYL)-2,6-DIOXO-3,6-DIHYDROPYRIMIDIN-1(2H)-YL]ACETATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure3/GIF/CB2429746.gif)
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