5-Chloropyrimidin-2-amine
- CAS NO.：5428-89-7
- Empirical Formula: C4H4ClN3
- Molecular Weight: 129.55
- MDL number: MFCD00014604
- EINECS: 226-581-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:15:43
What is 5-Chloropyrimidin-2-amine?
The Uses of 5-Chloropyrimidin-2-amine
5-Chloropyrimidin-2-amine is an useful reagent of research interest in the preparation of JAK2 inhibitors for the treatment of myeloproliferative disorders and SIRT2 inhibitors for the treatment of Huntington''s disease.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 567, 1942 DOI: 10.1021/ja01255a030
Properties of 5-Chloropyrimidin-2-amine
| Melting point: | 235-238 °C (lit.) |
| Boiling point: | 314.6±34.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 1.93±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 110914 |
| CAS DataBase Reference | 5428-89-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-5-chloropyrimidine(5428-89-7) |
| EPA Substance Registry System | 2-Pyrimidinamine, 5-chloro- (5428-89-7) |
Safety information for 5-Chloropyrimidin-2-amine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Chloropyrimidin-2-amine
| InChIKey | OQZMDDKDHRIGDY-UHFFFAOYSA-N |
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