5-Chloro-8-hydroxyquinoline

Synonym(s):5-Chloro-8-hydroxyquinoline

CAS NO.：130-16-5
Empirical Formula: C9H6ClNO
Molecular Weight: 179.6
MDL number: MFCD00006788
EINECS: 204-978-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is 5-Chloro-8-hydroxyquinoline?

Chemical properties

light green to grey powder

The Uses of 5-Chloro-8-hydroxyquinoline

antibacterial, antifungal

The Uses of 5-Chloro-8-hydroxyquinoline

Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Definition

ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

in vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.

in vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

Properties of 5-Chloro-8-hydroxyquinoline

Melting point:	122-124 °C(lit.)
Boiling point:	348.7±22.0 °C(Predicted)
Density	1.2364 (rough estimate)
vapor pressure	0.003Pa at 25℃
refractive index	1.5330 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	0.019g/l (experimental)
pka	3.77±0.10(Predicted)
form	Powder
color	Light green to gray
Sensitive	Light Sensitive
Merck	14,2422
BRN	5289
CAS DataBase Reference	130-16-5(CAS DataBase Reference)
NIST Chemistry Reference	8-Quinolinol, 5-chloro-(130-16-5)
EPA Substance Registry System	8-Quinolinol, 5-chloro- (130-16-5)

Safety information for 5-Chloro-8-hydroxyquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.