5-Chloro-2-nitropyridine

CAS NO.：52092-47-4
Empirical Formula: C5H3ClN2O2
Molecular Weight: 158.54
MDL number: MFCD03092916
EINECS: 639-354-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:25:47

What is 5-Chloro-2-nitropyridine?

The Uses of 5-Chloro-2-nitropyridine

5-Chloro-2-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_52092-47-4
To concentrated H2SO4 (50 ml) was added 30 % H2O2 (25mL) at 0 ??C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2SO4 (20 mL) was added at 0 ??C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorously stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine. 5-chloro-2-nitropyridine. MS m/z 159 (M+ 1)+.

Properties of 5-Chloro-2-nitropyridine

Melting point:	119-123℃
Boiling point:	275.3±20.0 °C(Predicted)
Density	1.489±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	-4.87±0.22(Predicted)
color	White to very faint yellow
InChI	InChI=1S/C5H3ClN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
CAS DataBase Reference	52092-47-4(CAS DataBase Reference)

Safety information for 5-Chloro-2-nitropyridine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.