5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
Synonym(s):N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium hexafluorophosphate;1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide hexafluorophosphate;2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate;HCTU
- CAS NO.：330645-87-9
- Empirical Formula: C11H15ClF6N5OP
- Molecular Weight: 413.69
- MDL number: MFCD04973268
- EINECS: 608-825-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:30
![5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Structural](https://img.chemicalbook.in/CAS/GIF/330645-87-9.gif)
What is 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate?
Chemical properties
White powder
The Uses of 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
Reagent for:
Synthesis of near-infrared pH activatable fluorescent probes
Synthesis of human β-amyloid by Fmoc chemistry
Stereoselective Horner-Wadsworth-Emmons olefination
Covalent ligation of fluorescent peptides to quantum dots
Alkylation of human telomere sequence
What are the applications of Application
HCTU is a coupling reagent
General Description
HCTU [1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides [2], in hindered couplings [3], and cyclizations [4].
The product number for this product was previously 01-62-0038.
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Properties of 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
| Melting point: | 185-190 °C |
| storage temp. | Store at +2°C to +8°C. |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| color | White to Almost white |
| CAS DataBase Reference | 330645-87-9(CAS DataBase Reference) |
Safety information for 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
| InChIKey | ZHHGTMQHUWDEJF-UHFFFAOYSA-N |
5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate manufacturer
JSK Chemicals
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Phone:+91-9879767984
Whatsapp: +91-9879767970
product: 330645-87-9 O- (1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 99%
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