5-Bromo-2-nitropyridine
- CAS NO.：39856-50-3
- Empirical Formula: C5H3BrN2O2
- Molecular Weight: 202.99
- MDL number: MFCD00160411
- EINECS: 609-748-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:36
What is 5-Bromo-2-nitropyridine?
Chemical properties
Colorless solid
The Uses of 5-Bromo-2-nitropyridine
5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.
Preparation
5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].
Synthesis Reference(s)
[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.
What are the applications of Application
5-Bromo-2-nitropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Properties of 5-Bromo-2-nitropyridine
| Melting point: | 148-150 °C (lit.) |
| Boiling point: | 292.3±20.0 °C(Predicted) |
| Density | 1.833±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -4.95±0.22(Predicted) |
| color | White to yellow to beige powder or crystal or chunks |
| BRN | 120878 |
| InChI | InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H |
| CAS DataBase Reference | 39856-50-3(CAS DataBase Reference) |
Safety information for 5-Bromo-2-nitropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Bromo-2-nitropyridine
| InChIKey | ATXXLNCPVSUCNK-UHFFFAOYSA-N |
| SMILES | C1([N+]([O-])=O)=NC=C(Br)C=C1 |
5-Bromo-2-nitropyridine manufacturer
SGT life sciences
4Y
Phone:+91-9866957562
Whatsapp: +91- 9866957562
product: 5-Bromo-2-nitropyridine 98%+
GK Chemicals
1Y
Phone:+91-7207279444
Whatsapp: +91-7207279444
product: 5-Bromo-2-nitropyridine 39856-50-3 98%
Lorven Biologics Pvt Ltd
1Y
Phone:+91-8884110005
Whatsapp: +91-8884110005
product: 2-Nitro-5-Bromo Pyridine 39856-50-3 98%
SAKEM LLP
1Y
Phone:+91-9676889998
Whatsapp: +91-9676889998
product: 2-Nitro -5-Bromo Pyridine 39856-50-3 98%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 2-Nitro-5-bromopyridine
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
You may like
-
5-Bromo-2-nitropyridine 39856-50-3 99%View Details
39856-50-3 -
39856-50-3 98%View Details
39856-50-3 -
2-Nitro-5-bromopyridine 98%View Details -
2-Nitro-5-bromopyridine 98%View Details -
5-Bromo-2-nitropyridine CAS 39856-50-3View Details
39856-50-3 -
5-Bromo-2-nitropyridine CAS 39856-50-3View Details
39856-50-3 -
5-Bromo-2-nitropyridine, 99% CAS 39856-50-3View Details
39856-50-3 -
5-Bromo-2-nitropyridine CAS 39856-50-3View Details
39856-50-3
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.