5-Bromo-2-nitropyridine

CAS NO.：39856-50-3
Empirical Formula: C5H3BrN2O2
Molecular Weight: 202.99
MDL number: MFCD00160411
EINECS: 609-748-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-09 10:27:52

What is 5-Bromo-2-nitropyridine?

Chemical properties

Colorless solid

The Uses of 5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.

Preparation

5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].

Synthesis Reference(s)

[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.

What are the applications of Application

5-Bromo-2-nitropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Properties of 5-Bromo-2-nitropyridine

Melting point:	148-150 °C (lit.)
Boiling point:	292.3±20.0 °C(Predicted)
Density	1.833±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	-4.95±0.22(Predicted)
color	White to yellow to beige powder or crystal or chunks
BRN	120878
InChI	InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
CAS DataBase Reference	39856-50-3(CAS DataBase Reference)

Safety information for 5-Bromo-2-nitropyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.