5-benzoylaminoindole

CAS NO.：6019-39-2
Empirical Formula: C15H12N2O
Molecular Weight: 236.27
MDL number: MFCD03055811
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-11 19:39:08

What is 5-benzoylaminoindole?

Description

Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts. The iPSCs developed using OAC2 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.

The Uses of 5-benzoylaminoindole

N-(1H-Indol-5-yl)benzamide is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process.

Properties of 5-benzoylaminoindole

Melting point:	165 - 167°C
Boiling point:	364.3±15.0 °C(Predicted)
Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	13.99±0.43(Predicted)
color	Pale Yellow

Safety information for 5-benzoylaminoindole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 5-benzoylaminoindole

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